The phenomenon of rosacea-rushes (theoretical aspects)

According to the decisions of international scientific forums, problem phenomenon rosacea (acne rosacea), a common dermatosis with numerous unexplained aspects etiopathogenesis is promising area modern medical research. The aim study was theoretical substantiation essential features mechanisms occurrence, development and clinical manifestations first signs in women reproductive age. use systematic analytical methodical approach assess data laboratory examinations rosacea, conducted different regions world, allowed establish originality such as appearance unexpected rushes limited areas face, accompanied by local redness heat skin differring significantly from similar other diseases or syndromes (menopause, migraine, etc.). It established that peculiarity relationship these characteristics (from English: rush, ruddy, redness, age women, reaction) allows indicate inherent this disease Rush-Ruddy-Rosacea-Reproduce-Reaction (abbreviated – «5-R»), key pathophysiological target which (as well whole) disorder set hierarchically dependent evolutionarily determined motivational need ensure function (both at cellular level extracellular structures ovaries, levels subcortical formations centers cortex cerebral hemispheres). rush closely related phenomena hypersensitivity bradykinin receptors, actinic elastosis, post erythematous telangiectasia. prospect further research on disorders functional systems molecules signaling compounds classes (hormones, eicosanoids, neuropeptides, kinins, cytokines others) pathogenesis disease.